TOLTRACOX
**TOLTRACOX** **Composition (per 1 ml):** – Toltrazuril …………………………..
25 mg **Description:** Toltrazuril is an anti-coccidial agent from the triazinetrione group, effective against *Eimeria spp.* It targets intracellular developmental stages of the parasites without affecting extracellular stages.
Toltrazuril reduces enzymatic activity in the respiratory chain, causing inflammation of the endoplasmic reticulum and Golgi apparatus, changes in the perinuclear space, and alteration of nuclear division.
In chickens and turkeys, toltrazuril is absorbed at a rate of no less than 50%.
Distribution is higher in the liver and kidneys, where it is quickly metabolized; the main metabolite is toltrazuril sulfone.
**Indications:** For the treatment of coccidiosis caused by: – **Chickens (broilers and breeders):** *Eimeria acervulina, E.
brunetti, E.
maxima, E.
necatrix, E.
tenella.* – **Turkeys:** *Eimeria adenoides, E.
meleagrimitis.* – **Calves:** For the prevention of coccidiosis symptoms and reduction of coccidia shedding in replacement calves in dairy farms with a confirmed history of coccidiosis caused by *Eimeria bovis* or *Eimeria zuernii.* – **Lambs:** For the prevention of coccidiosis symptoms and reduction of coccidia shedding in lambs in farms with a confirmed history of coccidiosis caused by *Eimeria crandallis* and *Eimeria ovinoidalis.* **Contraindications:** Hypersensitivity to the active ingredients.
**Administration and Dosage:** – **Poultry and Turkeys:** The recommended dose is 7 mg of toltrazuril per kg of body weight (equivalent to 28 ml of the product per 100 kg of body weight) daily for two consecutive days.
– **Calves:** Each animal should be treated with a single oral dose of 15 mg of toltrazuril per kg of body weight, which is equivalent to 6.0 ml of the oral suspension per 10 kg of body weight.
– **Lambs:** Each animal should be treated with a single oral dose of 20 mg of toltrazuril per kg of body weight, which is equivalent to 0.8 ml of the oral suspension per kg of body weight.
**Withdrawal Periods:** – **Poultry:** Meat: 16 days.
– **Turkeys:** Meat: 18 days.
– **Calves:** Meat: 63 days.
– **Lambs:** Meat: 42 days.
– **Eggs:** Not for use in laying hens producing eggs for human consumption.
**Storage:** Store in the original packaging below 25°C.
For veterinary use only.
Keep out of reach of children.
